"Anemia and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients". (9th August 2021)

• Record Type: Journal Article
• Authors: Danzinger, Sabine; Fügerl, Alexandra; Pfeifer, Christian; Bernathova, Maria; Tendl-Schulz, Kristina; Seifert, Michael
• Is Part Of: Cancer investigation. Volume 39:Number 6/7(2021)
• Page Start: 457
• Page End: 465
• Publication Date: 2021-08-09
• Subjects: Breast cancer -- cancer-related anemia -- neoadjuvant chemotherapy -- tumor response -- age at diagnosis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2021.1928166
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: We analyzed the effect of anemia on tumor response of patients with primary invasive breast cancer (BC) receiving neoadjuvant chemotherapy (NACT). The patient collective was very homogenous; finally, 74 BC patients with identical medication and duration of NACT were enrolled. After completion of NACT, 49 patients (66.2%) had a post-NACT Hb level <12 g/dl. In the anemic group, we found a tendency of lower median tumor response compared to nonanemic patients at this time (15 versus 17 mm, retrospectively, p = 0.18). Age at diagnosis significantly correlated with the difference of Hb [before initiation – after completion of NACT] (correlation coefficient = 0.40, p < 0.001).