Surface Characterization of Phenylpropanolamine Drug by Inverse Gas Chromatography. (22nd August 2013)

• Record Type: Journal Article
• Authors: Kumar, B. Praveen; Rani, P. Reddi; Reddy, T. Madhusudana; Reddy, K. S.
• Other Names: Knopf D. Academic Editor.; Starikov E. B. Academic Editor.; Yeow E. Academic Editor.
• Is Part Of: ISRN physical chemistry. Volume 2013(2013)
• Publication Date: 2013-08-22
• Subjects: Chemistry, Physical and theoretical -- Periodicals; Chemistry, Physical and theoretical; 35.10 physical chemistry: general; Periodicals; Electronic journals; 541
• DOI: 10.1155/2013/142687
• Languages: English
• ISSNs: 2090-7761

Abstract

Abstract : The surface thermodynamic properties can be used to understand the interactive potential of a drug surface with a solid or liquid excipient during its formulation and drug release process. The retention data were measured for n-alkanes and polar solutes at intervals of 5 K in the temperature range 318.15–333.15 K by Inverse Gas Chromatography (IGC) on the solid surface of phenylpropanolamine (PPA) drug. The retention data were used to evaluate the dispersive surface free energy, γ S d, and Lewis acid-base parameters, K a and K b, for the PPA drug. The values, γ S d, were decreasing linearly with increase of temperature and at 323.15 K the value was found to be 26.01 ± 0.40 mJ/m 2 . The specific components of enthalpy of adsorption of polar solutes have been applied to evaluate Lewis acid-base parameters. The K a and K b values were found to be 0.451 ± 0.033 and 0.824 ± 0.622, respectively, which suggests that the PPA surface contains more basic sites and interact strongly in the acidic environment.