Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1, 3, 4-Oxadiazole-2-thiol Moiety. (19th August 2013)

• Record Type: Journal Article
• Authors: Mohana, Kikkeri N.; Kumar, Chikkur B. Pradeep
• Other Names: Bellemin-Laponnaz S. Academic Editor.; Dinadayalane T. C. Academic Editor.
• Is Part Of: ISRN organic chemistry. Volume 2013(2013)
• Publication Date: 2013-08-19
• Subjects: Chemistry, Organic -- Periodicals; Organic Chemistry Phenomena; Chemistry, Organic; Chemistry, Organic; Periodical; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 547
• DOI: 10.1155/2013/620718
• Languages: English
• ISSNs: 2090-5149

Abstract

Abstract : A series of new 5-(2-amino-5-methylthiazol-4-yl)-1, 3, 4-oxadiazole-2-thiol derivatives 6 (a–j ) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, 1 H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes.