Acute Myocardial Infarction Caused by Filgrastim: A Case Report. (23rd December 2012)

• Record Type: Journal Article
• Authors: Bilir, Cemil; Engin, Hüseyin; Temi, Yasemin Bakkal; Toka, Bilal; Karabağ, Turgut
• Other Names: Ribera J. M. Academic Editor.; Tanaka K. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2012(2012)
• Publication Date: 2012-12-23
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2012/784128
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : Common uses of the granulocyte-colony stimulating factors in the clinical practice raise the concern about side effects of these agents. We presented a case report about an acute myocardial infarction with non-ST segment elevation during filgrastim administration. A 73-year-old man had squamous cell carcinoma of larynx with lung metastasis treated with the chemotherapy. Second day after the filgrastim, patient had a chest discomfort. An ECG was performed and showed an ST segment depression and negative T waves on inferior derivations. A coronary angiography had showed a critical lesion in right coronary arteria. This is the first study thats revealed that G-CSF can cause acute myocardial infarction in cancer patients without history of cardiac disease. Patients with chest discomfort and pain who are on treatment with G-CSF or GM-CSF must alert the physicians for acute coronary events.