The Coexistence of Systemic Lupus Erythematosus and Thyrotoxicosis: The Diagnostic Value of Antihistone Antibodies. (9th April 2012)

• Record Type: Journal Article
• Authors: Baleva, Marta; Nikolov, Krasimir; Manov, Emil; Stoikov, Anastas; Shabani, Rebhat; Dourmishev, Lyubomir; Nikolova, Milena
• Other Names: Aeberli D. Academic Editor.; Giusti A. Academic Editor.; Mikdashi J. Academic Editor.
• Is Part Of: Case reports in rheumatology. Volume 2012(2012)
• Publication Date: 2012-04-09
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Case studies -- Periodicals; Rheumatic Diseases; Connective Tissue Diseases; Rheumatology; Periodicals; Electronic journals; Case studies; Periodicals; 616.723
• DOI: 10.1155/2012/517059
• Languages: English
• ISSNs: 2090-6889

Abstract

Abstract : We report four female patients with Graves' disease with positive ANA antibodies and possibility for development of systemic lupus erythematosus. All four patients have been treated with antithyroid drugs. SLE symptoms have appeared from 4 to 12 months after the beginning of therapy with methysol in two of them. The third patient had no symptoms for SLE, but her ANA, anti-DNA, and antihistone antibodies had been positive at the time of the onset of thyrotoxicosis. The fourth patient had alopecia areata with positive ANA and antihistone antibodies.