Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae). (9th July 2013)

• Record Type: Journal Article
• Authors: Rodrigues, Danilo Fernando; Arenas Velásquez, Angela María; Cavaleiro, Carlos; Salgueiro, Lígia; Martins, Gilmárcio Zimmermann; Magalhães, Nathália Oliveira; Martins, Maria Bernadete Gonçalves; Cicarelli, Regina Maria Barretto; Moreira, Raquel Regina Duarte
• Other Names: De Souza M. A. Academic Editor.; Hisaeda H. Academic Editor.
• Is Part Of: ISRN infectious diseases. Volume 2013(2013)
• Publication Date: 2013-07-09
• Subjects: Communicable diseases -- Periodicals; 616.9
• DOI: 10.5402/2013/639275
• Languages: English
• ISSNs: 2090-8725

Abstract

Abstract : The composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1, 8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of Trypanosoma brucei (427 and 29-13 strains). The cytotoxicity index (CI50 ), using the MTT colorimetric method, showed that essential oils and 1, 8-cineole were inactive (>100 μ g·mL −1 . Nevertheless, caryophyllene oxide revealed a remarkable activity against both T. brucei strains (CI50 = 65.77 μ g·mL −1 and 24.53 μ g·mL −1, resp.), and the synergism between caryophyllene oxide plus pentamidine (1 : 1, v/v) highly increased the trypanocidal activity (<1.0 μ g·mL −1 ).