Cover Feature: Synthesis of 2‐Substituted 1, 2, 3‐Triazoles via an Intramolecular N–N Bond Formation (Eur. J. Org. Chem. 5/2020). Issue 5 (23rd January 2020)

• Record Type: Journal Article
• Authors: Chen, Cheng‐yi; Lu, Xiaowei; Holland, Mareike C.; Lv, Shichang; Ji, Xuebao; Liu, Wei; Liu, Jie; Depre, Dominique; Westerduin, Pieter
• Is Part Of: European journal of organic chemistry. Issue 5(2020)
• Page Start: 524
• Page End: 524
• Publication Date: 2020-01-23
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202000102
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Cover Feature shows how the in‐situ generated hydrazonium species leads to the formation of a wide variety of 2‐aryl‐1, 2, 3‐triazoles under very mild conditions. A preliminary computational DFT study on the reaction pathway suggest that the reaction likely follows an intramolecular S N 2 displacement mechanism with the trimethyl‐ammonium moiety serving as a good leaving group for the intramolecular N‐N bond formation. More information can be found in the Communication by C.‐y. Chen et al.