The bridge between transplantation and regenerative medicine: Beginning a new Banff classification of tissue engineering pathology. Issue 2 (16th January 2018)

• Record Type: Journal Article
• Authors: Solez, K.; Fung, K. C.; Saliba, K. A.; Sheldon, V. L. C.; Petrosyan, A.; Perin, L.; Burdick, J. F.; Fissell, W. H.; Demetris, A. J.; Cornell, L. D.
• Is Part Of: American journal of transplantation. Volume 18:Issue 2(2018)
• Page Start: 321
• Page End: 327
• Publication Date: 2018-01-16
• Subjects: bioengineering -- biomarker -- biopsy -- cellular transplantation (non‐islet) -- classification systems: Banff classification -- editorial/personal viewpoint -- pathology/histopathology -- regenerative medicine -- tissue injury and repair -- translational research/science; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.14610
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : The science of regenerative medicine is arguably older than transplantation—the first major textbook was published in 1901—and a major regenerative medicine meeting took place in 1988, three years before the first Banff transplant pathology meeting. However, the subject of regenerative medicine/tissue engineering pathology has never received focused attention. Defining and classifying tissue engineering pathology is long overdue. In the next decades, the field of transplantation will enlarge at least tenfold, through a hybrid of tissue engineering combined with existing approaches to lessening the organ shortage. Gradually, transplantation pathologists will become tissue‐(re‐) engineering pathologists with enhanced skill sets to address concerns involving the use of bioengineered organs. We outline ways of categorizing abnormalities in tissue‐engineered organs through traditional light microscopy or other modalities including biomarkers. We propose creating a new Banff classification of tissue engineering pathology to standardize and assess de novo bioengineered solid organs transplantable success in vivo. We recommend constructing a framework for a classification of tissue engineering pathology now with interdisciplinary consensus discussions to further develop and finalize the classification at future Banff Transplant Pathology meetings, in collaboration with the human cell atlas project. A possible nosology of pathologic abnormalities in tissue‐engineered organs is suggested. Abstract : The new Banff classification of tissue engineering pathology will characterize the pathologic abnormalities in bioengineered organs and tissues for transplantation, and will increasingly be used with the existing Banff classification of allograft pathology as prosthetic devices and tissue engineering become more common. See related articles on pages 293, 364, and 377 .