Effects of interstitial fluid pressure on shear wave elastography of solid tumors. (August 2021)

• Record Type: Journal Article
• Authors: Zheng, Yang; Jiang, Yuxuan; Cao, Yanping
• Is Part Of: Extreme mechanics letters. Volume 47(2021)
• Publication Date: 2021-08
• Subjects: Shear wave elastography -- Solid tumors -- Interstitial fluid pressure -- Inverse method; Mechanics -- Periodicals; Mechanics, Applied -- Periodicals; Mechanics; Electronic journals; Periodicals; 531.05
• DOI: 10.1016/j.eml.2021.101366
• Languages: English
• ISSNs: 2352-4316

Abstract

Abstract: Shear wave elastography (SWE) has been demonstrated to be promising in differentiating malignant tumors from benign ones. In this paper, a biomechanical model has been developed upon which an analytical solution has been derived to predict the effect of the interstitial fluid pressure (IFP) on SWE of solid tumors. Our model and analysis reveal a strong correlation between the IFP and shear wave velocity (SWV) in a solid tumor, which helps understand the physics underlying the elevated stiffness of malignant tumors as measured in clinics. Moreover, the analytical solution derived in this study may be used to infer the variation of IFP in a solid tumor​ in vivo in a non-invasive manner.