Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models. (14th January 2013)

• Record Type: Journal Article
• Authors: Quintans-Júnior, Lucindo; Moreira, José C. F.; Pasquali, Matheus A. B.; Rabie, Soheyla M. S.; Pires, André S.; Schröder, Rafael; Rabelo, Thallita K.; Santos, João P. A.; Lima, Pollyana S. S.; Cavalcanti, Sócrates C. H.; Araújo, Adriano A. S.; Quintans, Jullyana S. S.; Gelain, Daniel P.
• Other Names: Bahorun T. Academic Editor.; Miranda Fernandes Estevinho M. L. Academic Editor.; Vilanova E. Academic Editor.
• Is Part Of: ISRN toxicology. Volume 2013(2013)
• Publication Date: 2013-01-14
• Subjects: Toxicology -- Periodicals; Toxicology; Pharmacology; Toxicology; Pharmacology -- Periodicals; Toxicology -- Periodicals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 571.95
• DOI: 10.1155/2013/459530
• Languages: English
• ISSNs: 2090-6188

Abstract

Abstract : Objective . To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p -cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods . Evaluation of the in vitro antioxidant activity of (+)-camphene, p -cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results . p -Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p -cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion . (+)-Camphene, p -cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p -cymene and geranyl acetate.