Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation. (10th February 2013)

• Record Type: Journal Article
• Authors: Choi, Sik-Won; Moon, Seong-Hee; Yang, Hye Jeong; Kwon, Dae Young; Son, Young-Jin; Yu, Ri; Kim, Young Su; Kim, So I.; Chae, Eun Jeong; Park, Sang-Joon; Kim, Seong Hwan
• Other Names: Mo HuanBiao Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2013(2013)
• Publication Date: 2013-02-10
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2013/748687
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Antlers have been traditionally used for thousands of years as a natural product with medicinal and pharmaceutical properties. In developing healthy foods, Bacillus -mediated fermentation is widely used to enhance the biological activity of nutrients in foods. Recently, fermentation was shown to enhance the osteogenic activity of antlers. This study aimed to elucidate the antiresorptive activity of Bacillus -fermented antler and its mode of action. We found that Bacillus -fermented antler extract strongly inhibited osteoclast differentiation by downregulating the expression and activity of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). This extract also inhibited the activation of phospholipase C γ 2 (PLC γ 2), a signaling molecule that could regulate NFATc1 transcriptional activity. This suggested that Bacillus -fermented antler extract could inhibit PLC γ 2-NFATc1 signaling required for bone resorption and cell fusion. Consequently, Bacillus -fermented antler extract might benefit osteoclast-related disorders, including osteoporosis; furthermore, it may improve gastrointestinal activity.