KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature. (1st October 2020)

• Record Type: Journal Article
• Authors: Bouri, Sarah; Noël, Jean-Christophe; Catteau, Xavier; Al Hajj Obeid, Walid; Svistakov, Ilyas; Roumeguère, Thierry; D'Haene, Nicky; Rorive, Sandrine
• Other Names: Sheikh Mehraj Academic Editor.
• Is Part Of: Case reports in urology. Volume 2020(2020)
• Publication Date: 2020-10-01
• Subjects: Urology -- Periodicals; Urology -- Case studies -- Periodicals; Genitourinary organs -- Diseases -- Periodicals; Urologic Diseases; Genitourinary organs -- Diseases; Urology; Periodicals; Case studies; Periodicals; 616.6005
• DOI: 10.1155/2020/5419707
• Languages: English
• ISSNs: 2090-696X

Abstract

Abstract : Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm's tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.