Acute Effects of Two Angiotensin Receptor Blockers on Vascular Hemodynamics, Arterial Stiffness, and Oxidative Stress in Patients with Mild to Moderate Hypertension: An Open Label Parallel Group Study. (30th January 2013)

• Record Type: Journal Article
• Authors: Pathapati, Rama Mohan; Rajesh Kumar, Meriga; Chirra, Bhakthavatsala Reddy; Buchineni, Madhavulu; TR, Sujith; Devaraju, Sreebhushan Raju; Naidu, M. U. R.
• Other Names: Mugge A. Academic Editor.; Schoenhagen P. Academic Editor.
• Is Part Of: ISRN vascular medicine. Volume 2013(2013)
• Publication Date: 2013-01-30
• Subjects: Cardiology -- Periodicals; Cardiology; Vascular Diseases -- Periodicals; Vascular Surgical Procedures -- Periodicals; Periodicals; Electronic journals; 616.13
• DOI: 10.1155/2013/186759
• Languages: English
• ISSNs: 2090-5823

Abstract

Abstract : Introduction . We studied the acute effects of Olmesartan and Telmisartan at baseline and at the end of four weeks on indices of hemodynamics (heart rate HR, blood pressure BP), vascular (carotid femoral pulse wave velocity cf PWV, digital arterial tone expressed as Reflection index RI, and endothelial dependent vasodilator response EDVR), and oxidative stress (serum Malondialdehyde MDA) in hypertensive patients. Materials and Methods . The eligible patients were randomly allocated to either 20 mg Olmesartan or 40 mg Telmisartan. Results . 40 subjects received Olmesartan, and 29 received Telmisartan. After four weeks of treatment the mean changes from baseline in the Olmesartan group versus Telmisartan group are SBP - 9 . 8 ± 10 versus - 6 . 3 ± 12 mm Hg, P = 0.24 ; DBP - 6 . 1 ± 11 versus - 4 . 2 ± 12 . 5 mm Hg, P = 0.55 ; cf PWV - 1 . 6 ± 1 . 2 versus - 0 . 9 ± 1 . 4 m/s, P = 0.04 ; EDVR - 8 . 2 ± 5 . 2 versus - 5 . 2 ± 5 . 7 %, P = 0.04 ; and MDA - 1 . 9 ± 1 . 1 versus - 1 . 2 ± 1 . 2 η Mol/mL, P = 0.03 . Conclusion . Olmesartan showed a better improvement in cf PWV, EDVR, and MDA than Telmisartan with an identical reduction in blood pressure.