Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination. (4th December 2012)

• Record Type: Journal Article
• Authors: Gregersen, Tine; Holt, Nanna; Gronbaek, Henning; Vogel, Ida; Jørgensen, Lars J.; Krogh, Klaus
• Other Names: Abraham P. Academic Editor.; Lorenzo-Zúñiga V. Academic Editor.; Matsuhashi N. Academic Editor.; Yönem Ö. Academic Editor.
• Is Part Of: Case reports in gastrointestinal medicine. Volume 2012(2012)
• Publication Date: 2012-12-04
• Subjects: Gastroenterology -- Case studies -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Digestive organs -- Diseases; Gastroenterology; Electronic journals; Periodicals; Case studies; Periodicals; 616.33
• DOI: 10.1155/2012/185730
• Languages: English
• ISSNs: 2090-6528

Abstract

Abstract : Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids.