MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation. Issue Volume 49:Issue D1(2021) (24th August 2020)

• Record Type: Journal Article
• Authors: Ning, Lin; Cui, Tianyu; Zheng, Boyang; Wang, Nuo; Luo, Jiaxin; Yang, Beilei; Du, Mengze; Cheng, Jun; Dou, Yiying; Wang, Dong
• Is Part Of: Nucleic acids research. Volume 49:Issue D1(2021)
• Page Start: D160
• Page End: D164
• Publication Date: 2020-08-24
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkaa707
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: Many studies have indicated that non-coding RNA (ncRNA) dysfunction is closely related to numerous diseases. Recently, accumulated ncRNA–disease associations have made related databases insufficient to meet the demands of biomedical research. The constant updating of ncRNA–disease resources has become essential. Here, we have updated the mammal ncRNA–disease repository (MNDR, http://www.rna-society.org/mndr/ ) to version 3.0, containing more than one million entries, four-fold increment in data compared to the previous version. Experimental and predicted circRNA–disease associations have been integrated, increasing the number of categories of ncRNAs to five, and the number of mammalian species to 11. Moreover, ncRNA–disease related drug annotations and associations, as well as ncRNA subcellular localizations and interactions, were added. In addition, three ncRNA–disease (miRNA/lncRNA/circRNA) prediction tools were provided, and the website was also optimized, making it more practical and user-friendly. In summary, MNDR v3.0 will be a valuable resource for the investigation of disease mechanisms and clinical treatment strategies.