Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection. (7th May 2021)

• Record Type: Journal Article
• Authors: Casado, Jose L; Vizcarra, Pilar; Velasco, Hector; Hammerle, Johannes; McGee, Amaranta; Fernandez-Escribano, Marina; Vallejo, Alejandro
• Is Part Of: Journal of infectious diseases. Volume 224:Number 2(2021)
• Page Start: 241
• Page End: 245
• Publication Date: 2021-05-07
• Subjects: adaptive immune response -- convalescent -- duration -- healthcare workers -- immune response -- SARS-CoV-2; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab242
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection. Abstract : Twenty-two convalescent healthcare workers had a progressive decrease in specific antibodies against severe acute respiratory syndrome coronavirus 2 (41% seroreverted) and T-cell response (75% lost response to spike protein) in a 5.1-month period, associated with a lower initial adaptive immune response.