Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates. (4th June 2021)

• Record Type: Journal Article
• Authors: Moustafa, Ahmed M; Bianco, Colleen; Denu, Lidiya; Ahmed, Azad; Coffin, Susan E; Neide, Brandy; Everett, John; Reddy, Shantan; Rabut, Emilie; Deseignora, Jasmine; Feldman, Michael D; Rodino, Kyle G; Bushman, Frederic; Harris, Rebecca M; Chang Mell, Josh; Planet, Paul J
• Is Part Of: Open forum infectious diseases. Volume 8:Number 7(2021)
• Publication Date: 2021-06-04
• Subjects: B.1.1.7+E484K -- convergent -- vaccine -- escape mutation -- variant of concern; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab300
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.