Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study. (4th December 2020)

• Record Type: Journal Article
• Authors: Altaf, Mohammed; Lineburg, Katie E; Crooks, Pauline; Rehan, Sweera; Matthews, Katherine K; Neller, Michelle A; Ambalathingal, George R; Sinha, Debottam; Grant, Michelle; Hopkins, Peter M A; Chambers, Daniel; Khanna, Rajiv; Smith, Corey
• Is Part Of: Journal of infectious diseases. Volume 224:Number 2(2021)
• Page Start: 312
• Page End: 317
• Publication Date: 2020-12-04
• Subjects: cytomegalovirus -- T-cell immunity -- viral reactivation -- solid organ transplant; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa750
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant.