Plasma‐Assisted Deposition of Silk Fibroin on Different Surfaces. Issue 13 (14th June 2021)

• Record Type: Journal Article
• Authors: Arkhangelskiy, Artem; Maniglio, Devid; Bucciarelli, Alessio; Yadavalli, Vamsi K.; Quaranta, Alberto
• Is Part Of: Advanced materials interfaces. Volume 8:Issue 13(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-14
• Subjects: atmospheric pressure plasma -- plasma deposition -- poly(dimethylsiloxane) -- silk fibroin -- thin films -- Ti6Al4V alloy; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.202100324
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: The development of simple and versatile methods for the deposition of biocompatible coatings to protect or functionalize a range of materials with different shapes is an important challenge. In this study, a versatile, room‐temperature process is presented for the deposition of silk fibroin on different materials viz., glass, polyethylene terephthalate, Ti alloy, and poly(dimethylsiloxane). Coating with thin fibroin films is achieved using an atmospheric plasma torch, wherein a silk‐fibroin aerosol solution is used as the working gas. The method consists of two sequential processes: plasma modification of the surface, followed by plasma‐assisted deposition. This allows enhanced adhesion of the protein to the underlying surfaces, and the deposition even on non‐planar and flexible substrates. The deposited films are characterized by optical microscopy, atomic force microscopy, and scanning electron microscopy. Primary and secondary structures of the surface‐attached fibroin films are investigated by Fourier transform infrared spectroscopy. The proposed approach offers a tunable and controllable strategy for the controlled deposition of proteins on complex surfaces, for a wide range of biomedical and technological applications, including dentistry and bioelectronics. Abstract : A novel method for deposition of silk‐fibroin‐derived protein using atmospheric plasma torch is presented, allowing the production of uniform thin films on metals with complex geometry, glass, and flexible materials such as polyethylene terephthalate and poly(dimethylsiloxane). Surface modification by plasma provides controlled thickness conformal coatings and effective adhesion of silk fibroin to substrates.