SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama. (July 2021)

• Record Type: Journal Article
• Authors: Díaz, Yamilka; Ortiz, Anyuri; Weeden, Adriana; Castillo, Daniel; González, Claudia; Moreno, Brechla; Martínez-Montero, Mabel; Castillo, Marlene; Vasquez, Grettel; Sáenz, Lisseth; Franco, Danilo; Pitti, Yaneth; Chavarria, Oris; Gondola, Jessica; Moreno, Ambar M.; Ábrego, Leyda; Beltrán, Davis; Guerra, Ilka; Chang, Jim; Chaverra, Zumara; Guerrero, Isela; Valoy, Alejandra; Gaitán, Melissa; Araúz, Dimelza; Morán, Ernesto; Chen-Germán, Maria; Valdespino, Elimelec; Rodríguez, Rita; Corrales, Rita; Chen-Camaño, Roderick; Pascale, Juan Miguel; Martínez, Alexander A.; López-Vergès, Sandra;
• Is Part Of: International journal of infectious diseases. Volume 108(2021)
• Page Start: 588
• Page End: 591
• Publication Date: 2021-07
• Subjects: SARS-CoV-2 -- COVID-19 -- Panama -- Reinfection -- Mutation; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.06.004
• Languages: English
• ISSNs: 1201-9712

Abstract

Graphical abstract: Highlights: SARS-CoV-2 reinfection by viruses from 2 different endemic lineages from Panama. Both infections caused mild symptoms in immunocompetent patient with no comorbidities. Reinfection has 21 nucleotide substitutions, 1 deletion, 1 insertion compared to 1st. Amino acid changes in the Spike, orf1a, helicase, orf3a, N proteins. Spike mutations D614G, L452R in 2nd virus: better transmission and immune escape. Abstract: We report a case of reinfection by SARS-CoV-2 with the second virus harboring amino acid changes in the Spike protein (141-143del, D215A, ins215AGY, L452R, D614G), orf1a, helicase, orf3a, and Nucleocapside. The virus associated with the reinfection, from an endemic lineage containing the S:L452R immune escape mutation, was circulating in Panama at the time.