An Efficient One-Pot Multicomponent Synthesis of 4-Aza-Podophyllotoxin Derivatives in Ionic Liquid. (24th October 2013)

• Record Type: Journal Article
• Authors: Naeimi, Hossein; Rashid, Zahra; Zarnani, Amir Hassan; Ghahremanzadeh, Ramin
• Other Names: Penoni Andrea Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2013(2013)
• Publication Date: 2013-10-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2013/169695
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A simple, green, and efficient procedure for the synthesis of 4-aza-podophyllotoxin derivatives by using a one-pot three-component reaction of benzaldehydes, 1, 3-cyclohexanediones, and anilinolactones in the presence of catalytic amount of alum in 1-butyl-3-methylimidazolium triflate as green media is described. This reaction proceeded under mild conditions with the use of an inexpensive and readily available catalyst, high to excellent yields, and simple workup procedure.