Ginseng Is Useful to Enhance Cardiac Contractility in Animals. (4th February 2014)

• Record Type: Journal Article
• Authors: Lin, Jia-Wei; Cherng, Yih-Giun; Chen, Li-Jen; Niu, Ho-Shan; Chang, Chen Kuei; Niu, Chiang-Shan
• Other Names: Cheng Juei-Tang Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-02-04
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/723084
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Ginseng has been shown to be effective on cardiac dysfunction. Recent evidence has highlighted the mediation of peroxisome proliferator-activated receptors (PPARs) in cardiac function. Thus, we are interested to investigate the role of PPAR δ in ginseng-induced modification of cardiac contractility. The isolated hearts in Langendorff apparatus and hemodynamic analysis in catheterized rats were applied to measure the actions of ginseng ex vivo and in vivo . In normal rats, ginseng enhanced cardiac contractility and hemodynamic d P / d t max significantly. Both actions were diminished by GSK0660 at a dose enough to block PPAR δ . However, ginseng failed to modify heart rate at the same dose, although it did produce a mild increase in blood pressure. Data of intracellular calcium level and Western blotting analysis showed that both the PPAR δ expression and troponin I phosphorylation were raised by ginseng in neonatal rat cardiomyocyte. Thus, we suggest that ginseng could enhance cardiac contractility through increased PPAR δ expression in cardiac cells.