High-Dose Chemotherapy for Adult-Type Ovarian Granulosa Cell Tumors: A Retrospective Study of the European Society for Blood and Marrow Transplantation. Issue 2 (1st February 2017)

• Record Type: Journal Article
• Authors: De Giorgi, Ugo; Nicolas-Virelizier, Emmanuelle; Badoglio, Manuela; Bader, Peter; Richard, Sandrine; Maertens, Johan; Lanza, Francesco; Bregni, Marco
• Is Part Of: International journal of gynecological cancer. Volume 27:Issue 2(2017)
• Page Start: 248
• Page End: 251
• Publication Date: 2017-02-01
• Subjects: Adult-type ovarian granulosa cell tumors -- Ovarian cancer -- Salvage chemotherapy -- High-dose chemotherapy; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000882
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: A few small retrospective series reported results with salvage chemotherapy for malignant ovarian adult-type granulosa cell tumors (GCTs), whereas no data are available on high-dose chemotherapy (HDC) with hematopoietic progenitor cell support (HSCS) in these patients. The aim of this study was to analyze the available data of HDC for adult-type GCTs. Methods: We conducted a retrospective analysis of ovarian cancer treated with salvage HDC registered with the European Society for Blood and Marrow Transplantation. Results: Of 203 adult female patients with a diagnosis of nonepithelial ovarian cancer treated with salvage HDC with HSCS and registered with the European Society for Blood and Marrow Transplantation, 4 (2%) patients were affected by GCTs. All 4 patients had ovarian adult-type GCTs that relapsed/progressed after first-line chemotherapy. The conditioning regimens included a platinum agent in all 4 patients. Bone marrow recovery was promptly achieved; neither treatment-related deaths or life-threatening toxicities occurred. At a median follow-up of 8.5 months, all patients reported a progressive disease. The patient who underwent multicycle HDC enjoyed a long-term remission of 84 months before progression and is the only one alive after 94+ months. Conclusions: We showed for the first time a case with long-lasting response to salvage multicycle HDC and HSCS in adult-type GCTs.