Identification of immune‐activating metabolite for enhancing T cell therapy of cancer. Issue 7 (18th May 2021)

• Record Type: Journal Article
• Authors: Cong, Boyi; Cui, Zenghui; Cao, Xuetao
• Is Part Of: Cancer communications. Volume 41:Issue 7(2021)
• Page Start: 535
• Page End: 537
• Publication Date: 2021-05-18
• Subjects: Cancer -- Periodicals; Neoplasms; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.994005
• DOI: 10.1002/cac2.12177
• Languages: English
• ISSNs: 2523-3548

Abstract

Abstract : In this Research Highlight, we summarized the results from a study by Wu et al . published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8 + T cells towards tumour through lymphocyte‐specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy.