Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1, 2, 3, 6, -tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action. (31st August 2013)

• Record Type: Journal Article
• Authors: Hwang, Deok-Sang; Kim, Hyo Geun; Jang, Jun-Bock; Oh, Myung Sook
• Other Names: Yin Chang Shik Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2013(2013)
• Publication Date: 2013-08-31
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2013/976270
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease. Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection. In the present study, we were to investigate the effect of DJS and its mechanism in an in vitro and in vivo model of Parkinson's disease (PD). In primary mesencephalic culture system, DJS attenuated the dopaminergic cell damage induced by 1-methyl-4-phenylpyridine toxicity, and it inhibited production of inflammatory factors such as tumor necrosis factor α (TNF- α ), nitric oxide (NO), and activation of microglial cells. Then, we confirmed the effect of DJS in a mouse PD model induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). In the pole test, DJS at 50 mg/kg/day for 5 days showed increase of motor activity showing shortened time to turn and locomotor activity compared with the MPTP only treated mice. In addition, DJS significantly protected nigrostriatal dopaminergic neuron from MPTP stress. Moreover, DJS showed inhibition of gliosis in the substantia nigra pars compacta. These results have therapeutic implications for DJS in the treatment of PD via anti-inflammatory effects.