Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration. Issue 14 (5th May 2021)

• Record Type: Journal Article
• Authors: Xie, Chang; Ye, Jinchun; Liang, Renjie; Yao, Xudong; Wu, Xinyu; Koh, Yiwen; Wei, Wei; Zhang, Xianzhu; Ouyang, Hongwei
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 14(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-05
• Subjects: bone regeneration -- endochondral ossification -- precultured grafts -- tissue‐engineered grafts; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202100408
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The failure to repair critical‐sized bone defects often leads to incomplete regeneration or fracture non‐union. Tissue‐engineered grafts have been recognized as an alternative strategy for bone regeneration due to their potential to repair defects. To design a successful tissue‐engineered graft requires the understanding of physicochemical optimization to mimic the composition and structure of native bone, as well as the biological strategies of mimicking the key biological elements during bone regeneration process. This review provides an overview of engineered graft‐based strategies focusing on physicochemical properties of materials and graft structure optimization from macroscale to nanoscale to further boost bone regeneration, and it summarizes biological strategies which mainly focus on growth factors following bone regeneration pattern and stem cell‐based strategies for more efficient repair. Finally, it discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration. Abstract : This review provides an overview of engineered graft‐based strategies focusing on physicochemical properties of materials and structure optimization from macroscale to nanoscale, and summarizes biological strategies which mainly focus on growth factors and stem cells for more efficient repair. It also discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration.