Acute Hepatitis Induced by Intravesical BCG Therapy: A Rare but Serious Complication. (25th June 2021)

• Record Type: Journal Article
• Authors: Abid, Hakima; Figuigui, Mouna; Adil Ibrahimi, Sidi; El Abkari, Mohamed; Mzyiene, Mohamed; Ennaciri, Soufiane; Justin Ziba, Ouima; Fassi, Mohamed Jamal El; Tahiri Elousrouti, Layla; Chbani, Laila
• Other Names: Komatsu Haruki Academic Editor.
• Is Part Of: Case reports in hepatology. Volume 2021(2021)
• Publication Date: 2021-06-25
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; Liver Diseases; Liver; Liver; Liver -- Diseases; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.36
• DOI: 10.1155/2021/4574879
• Languages: English
• ISSNs: 2090-6587

Abstract

Abstract : Bacillus Calmette and Guérin (BCG), widely used as a vaccination to prevent tuberculosis, is also used as immunotherapy, by intrabladder instillation, to treat superficial bladder cancers and prevent recurrence. Complications following instillation of BCG are most often localized reactions, such as cystitis or hematuria. They can more rarely be generalized and potentially severe such as hepatitis, pneumopathies, aortitis, and localization to hematopoietic tissue. We have reported the observation of a 47-year-old patient followed up for a bladder tumor operated for transurethral resection of the bladder, then having benefited from an instillation of BCG therapy complicated by occurrence a week later of an acute hepatitis. The diagnostic time was 2 days, and the outcome was favorable with corticosteroid therapy.