Association of two polymorphisms of miRNA-146a rs2910164 (G > C) and miRNA-499 rs3746444 (T > C) with asthma: a meta-analysis. (3rd August 2021)

• Record Type: Journal Article
• Authors: Dong, Jing; Sun, Dandan; Lu, Fangting
• Is Part Of: Journal of asthma. Volume 58:Number 8(2021)
• Page Start: 995
• Page End: 1002
• Publication Date: 2021-08-03
• Subjects: Asthma -- microRNA -- polymorphisms -- meta-analysis; Asthma -- Periodicals; 616.238005
• DOI: 10.1080/02770903.2020.1759085
• Languages: English
• ISSNs: 0277-0903

Abstract

Abstract: Objective: To conduct a meta-analysis to determine the association between two single nucleotide polymorphisms (SNPs) miRNA146a rs2910164 (G > C) and miRNA-499 rs3746444 (T > C) and asthma risk. Data Sources: PubMed and Embase (updated May 17, 2019). Keywords: (microRNA OR microRNAs) AND (polymorphism OR polymorphisms) AND (Asthmas OR Bronchial Asthma OR Asthma, Bronchial). Results: Six eligible case-control studies (2441 asthma cases and 3044 controls) met our inclusion criteria. A trend of increased asthma risk was indicated by the heterozygote model (miR-499: TC versus TT, OR = 1.38, 95% CI = 1.06–1.79, P < 0.01) and the dominant model (miR-499: TC + CC versus TT, OR = 1.60, 95% CI = 1.07–2.39, P < 0.01) of miRNA-499 rs3746444. Polymorphisms rs2910164 in miRNA-146a of the allele model (miR-146a: C versus G, OR = 0.84, 95% CI = 0.74–0.96, P = 0.238), homozygote model (miR-146a: CC versus GG, OR = 0.68, 95% CI = 0.51–0.91, P = 0.213), recessive model (miR-146a: CC versus GC + GG, OR = 0.75, 95% CI = 0.60–0.94, P = 0.149) indicated a decreased risk of asthma. Conclusions: The miR-499 rs3746444 (T > C) polymorphism is associated with asthma susceptibility and miRNA-146a rs2910164 (G > C) polymorphism has a protective role against susceptibility to asthma.