Circulating Long Non-Coding RNA GAS5: A Non-Invasive Molecular Marker for Prognosis, Response to Treatment and Survival in Non-Small Cell Lung Cancer. (9th August 2021)

• Record Type: Journal Article
• Authors: Al Mourgi, Majed; El Askary, Ahmad; Gharib, Amal F.; Alzahrani, Rajab; Banjer, Hamsa Jameel; Elsawy, Wael H.; Al Ghamdi, Abd El-Rahman; Raafat, Nermin
• Is Part Of: Cancer investigation. Volume 39:Number 6/7(2021)
• Page Start: 505
• Page End: 513
• Publication Date: 2021-08-09
• Subjects: Non-small-cell lung cancer -- qRT-PCR -- lncRNA-GAS5 -- plasma -- tissues; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2021.1928167
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Circulating long non-coding RNAs (lncRNA) are dysregulated in several diseases, especially cancers, e.g. non-small-cell lung cancer (NSCLC). Of specific notice in this regard is growth arrest-specific 5 gene (lncRNA GAS5), which is principally recognised as a tumor suppressor gene in numerous cancers. Functionally, GAS5 is involved in arresting cellular growth and induction of apoptosis. We analysed plasma GAS5 expression by qRT-PCR in 100 patients with NSCLC before and after tumour resection surgery. We reported a downregulation of GAS5 expression in NSCLC tissue and plasma, which showed elevation after surgery. Downregulation of GAS5 was associated with poor prognosis of NSCLC patients.