Intra-QT Spectral Coherence as a Possible Noninvasive Marker of Sustained Ventricular Tachycardia. (15th July 2014)

• Record Type: Journal Article
• Authors: Piccirillo, Gianfranco; Moscucci, Federica; Persi, Alessandro; Di Barba, Daniele; Pappadà, Maria Antonella; Rossi, Pietro; Quaglione, Raffaele; Nguyen, Bich Lien; Barillà, Francesco; Casenghi, Matteo; Magrì, Damiano
• Other Names: Ng Jason Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-07-15
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/583035
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death (SCD). We, therefore, assessed possible difference in spectral coherence between the ECG segment extending from the q wave to the T wave peak (QT p ) and the one from T wave peak to the T wave end ( T e ) between patients with and without Holter ECG-documented sustained ventricular tachycardia (VT). None of the QT variability indexes as well as most of the coherences and RR power spectral variables significantly differed between the two groups except for the Q T p - T e spectral coherence. The latter was significantly lower in patients with sustained VT than in those without (0.508 ± 0.150 versus 0.607 ± 0.150, P < 0.05 ). Although the responsible mechanism remains conjectural, the Q T p - T e spectral coherence holds promise as a noninvasive marker predicting malignant ventricular arrhythmias.