Analysis of the Associations between Vitamin D and Albuminuria or β-Cell Function in Chinese Type 2 Diabetes. (23rd April 2014)

• Record Type: Journal Article
• Authors: Cai, Xiaoling; Hu, Zhaoheng; Chen, Ling; Han, Xueyao; Ji, Linong
• Other Names: Rizvi Ali Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-04-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/640909
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Objective . To investigate the associations of 25-(OH)D and β -cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods . In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results . Comparison between patients with and without 25-(OH)D deficiency indicated that, compared with patients with 25-(OH)D ≥ 50 nmol/L, patients with 25-(OH)D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15 ± 10.30 mg/g versus 52.79 ± 14.97 mg/g). Multiple regression analysis indicated that 25-(OH)D was independently and negatively correlated with urine ACR (OR = 0.985, 95%CI 0.972–0.999, P = 0.03 ), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH)D (34.49 ± 13.52 nmol/L versus 37.46 ± 13.6 nmol/L, P = 0.00 ). Analysis of the associations of 25-(OH)D and β -cell function or insulin resistance showed that 25-(OH)D may not correlate with β -cell function or insulin resistance. Conclusion . 25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with β -cell function or insulin resistance.