Correlation Between E6 and E7 Oncogenes and Malignant Transformation of Laryngeal Papillomatosis (LP) with Human Papillomavirus (HPV) in Pediatric Population. (15th July 2021)

• Record Type: Journal Article
• Authors: Khreefa, Zaid; Isaac, Vivian; Poulik, Janet; Felix, Richard; Selwanes, Wasim; Mangal, Ruchi; Dereje, Pheven; Fatouh, Khairya A.; Shehata, Bahig M.
• Is Part Of: Fetal and pediatric pathology. Volume 40:Number 4(2021)
• Page Start: 290
• Page End: 294
• Publication Date: 2021-07-15
• Subjects: laryngeal papillomatosis -- malignant transformation -- oncogene E6 -- E7 -- low-risk HPV -- pediatrics; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2019.1707921
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Introduction: Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods : Among 187 patients identified in our institution with LP, four cases showed malignant transformation to invasive squamous carcinoma. Results: These patients had tumors with HPV viruses that showed high expression of oncogene E6 and E7 and low expression of E2. Conclusion: Malignant transformation of LP is associated with oncogenic expression of E6 and E7.