Enantioselective synthesis of C3 substituted benzofuroindolines via catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p-benzoquinones. (20th July 2021) - Lu, Zhen-yu
Graphical abstract: Highlights: An enantioselective [3 + 2] cyclization of 3-substituted indoles with p- benzoquinones were developed. Variou C3 substituted benzofuroindolines compounds were obtained. The chiral phosphoric acid were applied for catalyzed asymmetric of p- benzoquinones. Abstract: An efficient catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p- benzoquinones has been realized using a binol-chiral phosphoric acid. A large variety of C3 substituted benzofuroindolines compounds were achieved in moderate to high yields (up to 91% yield) and excellent enantioselectivities (up to 94% ee).