PBAT hollow porous microfibers prepared via electrospinning and their functionalization for potential peptide release. (September 2021)

• Record Type: Journal Article
• Authors: Liu, Yufei; Yang, Long; Chen, Guijing; Liu, Zhentao; Lu, Tao; Yang, Yong; Yu, Jia; Kang, Dongdong; Yan, Wei; He, Min; Qin, Shuhao; Yu, Jie; Ye, Chuan; Luo, Heng
• Is Part Of: Materials & design. Volume 207(2021)
• Publication Date: 2021-09
• Subjects: Hollow porous microfibers -- Electrospinning -- Peptide -- Release; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2021.109880
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: Polybutylene adipate terephthalate hollow porous microfibers (HPMFs) are prepared. The loading capacity of polypeptide on HPMFs is improved compared with on MFs. The inhibition rates of RGD@HPMFs on HeLa and A549 are higher than RGD@HPMFs by 14.1% and 6.9%, respectively. Controlled loading and sustained release of polypeptide challenges are addressed. Abstract: Although microfiber (MF) loaded polypeptides have been widely studied in the field of medicine, load control and slow release remain significant challenges. Herein, polybutylene adipate terephthalate (PBAT) hollow porous MFs (HPMFs) were prepared by improving and regulating the groups and structures of the MFs to address these challenges. The capacity of the HPMFs for the loading of polypeptide can be improved. Measurements involving the use of X-ray photoelectron, energy-dispersive, and ultraviolet (UV) spectroscopies in conjunction with scanning electron microscopy measurements showed that the amount of polypeptide (arginylglycylaspartic acid, RGD) loaded on the HPMFs was significantly higher than that loaded on the MFs. Animal cell experiments revealed that PBAT grafted MAH has good bioactivity. By loading RGD onto HPMFs and MFs, RGD@HPMFs and RGD@MFs were obtained. A study on HeLa and A549 cancer cells showed that the inhibition rates of RGD@HPMFs were higher than that of RGD@MFs by 14.1% and 6.9%, respectively. The results obtained herein show that HPMF scaffold preparation by improving the material groups and regulating the structure of MFs can address the challenges associated with control of the load and sustained release of polypeptides and other drugs.