A New Spike Sorting Algorithm Based on Continuous Wavelet Transform and Investigating Its Effect on Improving Neural Decoding Accuracy. (1st August 2021)

• Record Type: Journal Article
• Authors: Soleymankhani, Amir; Shalchyan, Vahid
• Is Part Of: Neuroscience. Volume 468(2021)
• Page Start: 139
• Page End: 148
• Publication Date: 2021-08-01
• Subjects: continuous wavelet transform -- neural decoding -- optimization -- partial least squares -- spike sorting; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2021.05.036
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Improving the spike sorting accuracy can improve neural decoding performance. A spike sorting algorithm is presented that uses optimized continuous wavelet coefficients as features. In the simulation study, the proposed spike sorting outperformed both the WaveClus and PCA-based spike sorting algorithms. In real data test, the proposed spike sorting improved neural decoding performance compared to PCA-based spike sorting. Abstract: Spike sorting is an essential step in extracting neuronal discharge patterns which help to decode different activities in the neural system. Therefore, improving the spike sorting accuracy can improve neural decoding performance subsequently. Although many methods are suggested for spike sorting, few studies have evaluated their effect on neural decoding performance. In this paper, a method of spike sorting based on an optimized selection of the parameters in the continuous wavelet transform (CWT) is proposed. The proposed algorithm was tested on a simulated dataset and two publicly available benchmark datasets to evaluate its performance in spike sorting. To evaluate the effect of utilizing different spike sorting algorithms on neural decoding performance, real data was used in which the aim was to decode the force applied by the rat's hand to a pedal continuously from the intra-cortical data of the primary motor area of the cortex. The extracted neuronal firing rates by the spike sorting algorithms were applied to a partial least squares regression to decode the force signal. In the simulation study, the proposed spike sorting algorithm based on optimized wavelet parameter selection outperformed both the WaveClus spike sorting and traditional PCA-based spike sorting algorithms. The results showed the superiority of the spike sorting algorithm based on optimal wavelet parameters compared to classical discrete wavelet transform (DWT) or PCA-based spike sorting methods in decoding real intracortical data. Overall, the results indicate that it is possible to improve neural decoding performance by improving the spike sorting accuracy.