Nanoscale Metal-Organic Frameworks: Recent developments in synthesis, modifications and bioimaging applications. (October 2021)

• Record Type: Journal Article
• Authors: Sohrabi, Hessamaddin; Javanbakht, Siamak; Oroojalian, Fatemeh; Rouhani, Farzaneh; Shaabani, Ahmad; Majidi, Mir Reza; Hashemzaei, Mahmoud; Hanifehpour, Younes; Mokhtarzadeh, Ahad; Morsali, Ali
• Is Part Of: Chemosphere. Volume 281(2021)
• Publication Date: 2021-10
• Subjects: Bioimaging -- Metal-organic frameworks -- Magnetic resonance imaging -- Computed tomography -- Positron-emission tomography -- Optical imaging; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2021.130717
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Porous Metal-Organic Frameworks (MOFs) have emerged as eye-catching materials in recent years. They are widely used in numerous fields of chemistry thanks to their desirable properties. MOFs have a key role in the development of bioimaging platforms that are hopefully expected to effectually pave the way for accurate and selective detection and diagnosis of abnormalities. Recently, many types of MOFs have been employed for detection of RNA, DNA, enzyme activity and small-biomolecules, as well as for magnetic resonance imaging (MRI) and computed tomography (CT), which are valuable methods for clinical analysis. The optimal performance of the MOF in the bio-imaging field depends on the core structure, synthesis method and modifications processes. In this review, we have attempted to present crucial parameters for designing and achieving an efficient MOF as bioimaging platforms, and provide a roadmap for researchers in this field. Moreover, the influence of modifications/fractionalizations on MOFs performance has been thoroughly discussed and challenging problems have been extensively addressed. Consideration is mainly focused on the principal concepts and applications that have been achieved to modify and synthesize advanced MOFs for future applications. Graphical abstract: Image 1 Highlights: A comprehensive look at all three aspects of the synthesis, modifications/functionalization and use of MOF in bioimaging. Different types of bioimaging using MOFs. Challenges and future perspectives of MOF in bioimaging application.