Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis. (August 2021)

• Record Type: Journal Article
• Authors: Avan, Abolfazl; Amiri, Amin; Mokhber, Naghmeh; Erfanian, Mahdiyeh; Cipriano, Lauren E.; Stranges, Saverio; Shojaeianbabaei, Golnaz; Abootalebi, Shahram; Azarpazhooh, M. Reza
• Is Part Of: Journal of clinical neuroscience. Volume 90(2021)
• Page Start: 124
• Page End: 131
• Publication Date: 2021-08
• Subjects: +85S The Vantaa +85 study [16, 20] -- 90+S The 90+ study [19] -- ACT The Adult Changes in Thought study [5, 32] -- AD Alzheimer's disease -- AZSAND The Arizona Study of Aging and Neurodegenerative Disorders [18] -- CAA Cerebral amyloid angiopathy -- CC75CS The Cambridge City over-75s Cohort Study [24] -- CI Confidence interval -- HAAS The Honolulu-Asia Aging Study [21] -- HiS The Hisayama Study [15] -- HS Hippocampal sclerosis -- LB Lewy body -- MAP The Memory and Aging Project 1 -- MRC-CFAS The Medical Research Council Cognitive Function and Ageing Study [30] -- OBAS The Oregon Brain Aging Study [23] -- NS The Nun Study [21] -- OR Odds ratio -- ROS The Religious Order Study 2011 [22] -- ROS-MAP The Religious Order Study and the Memory and Aging Project [17]; Lewy body -- Cerebral amyloid angiopathy -- Hippocampal sclerosis -- Dementia -- Prevalence -- Community-dwelling elderly; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2021.05.044
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We found 14 studies comprising 2197 demented and 2104 non-demented community people. Dementia risk increased with Lewy body, hippocampal sclerosis, and amyloid angiopathy. With neocortical Lewy bodies, 20% of participants remained non-demented until death. With bilateral hippocampal sclerosis, 17% of people remained non-demented until death. With moderate/severe amyloid angiopathy, 42% remained non-demented until death. Abstract: Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia. Methods: We searched for community-based cohorts with postmortem brain autopsy until 1 January 2020. We calculated the summary risk difference and 95% confidence interval (95% CI) using a random-effects model in R. Results: We found 12 articles, comprising 2197 demented and 2104 non-demented participants. LB, HS, CAA were prevalent lesions among community-dwelling elderly (15%, 10%, and 24%, respectively). These significantly increased the risk of dementia (LB: risk difference 38%, 95% CI 20–56%, HS: 34%, 24–44%, CAA: 19%, 3–34%). 20% of cases with neocortical LB, 17% with bilateral HS, and 42% with moderate/severe CAA pathology remained non-demented by death. Discussion: LB or HS or CAA are common neuropathologies among community-dwelling elderly. Although these lesions independently are associated with dementia, many remain non-demented, by death.