Fructose-1, 6-bisphosphate promotes PI3K and glycolysis in T cells?. (August 2021)

• Record Type: Journal Article
• Authors: Icard, Philippe; Alifano, Marco; Donnadieu, Emmanuel; Simula, Luca
• Is Part Of: Trends in endocrinology and metabolism. Volume 32:Number 8(2021)
• Page Start: 540
• Page End: 543
• Publication Date: 2021-08
• Subjects: T cell -- metabolism -- Warburg effect -- fructose-1, 6-bisphosphate -- citrate -- cancer cell; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2021.04.013
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : We propose that fructose-1, 6-bisphosphate (F-1, 6-BP) promotes a feedback loop between phosphofructokinase-1 (PFK1), phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), and PFK2/PFKFB3, which enhances aerobic glycolysis and sustains effector T (Teff ) cell activation, while oxidative metabolism is concomitantly downregulated. This regulation, promoted by low citrate and mitochondrial ATP synthesis, also sustains the Warburg effect in cancer cells.