Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats. (September 2021)

• Record Type: Journal Article
• Authors: Suwanjang, Wilasinee; Ruankham, Waralee; Chetsawang, Banthit; Mukda, Sujira; Ngampramuan, Sukhonthar; Srisung, Sujitra; Prachayasittikul, Virapong; Prachayasittikul, Supaluk
• Is Part Of: Neurochemistry international. Volume 148(2021)
• Publication Date: 2021-09
• Subjects: Chronic stress -- Spilanthes acmella Murr. -- Mitochondrial dynamics -- Depression; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2021.105083
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Chronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function. Highlights: S. acmella Murr. extract treatment attenuated oxidative stress, and enhanced the upregulation of mitochondrial MnSOD and ATPase in chronic restraint stress. S. acmella Murr. extract suppressed mitochondrial fission but improved mitochondrial function in the chronic restraint stress.