Exposure estimates of phthalates and DINCH from foods and personal care products in comparison with biomonitoring data in 24-hour urine from the Norwegian EuroMix biomonitoring study. (October 2021)

• Record Type: Journal Article
• Authors: Gkrillas, A.; Dirven, H.; Papadopoulou, E.; Andreassen, M.; Hjertholm, H.; Husøy, T.
• Is Part Of: Environment international. Volume 155(2021)
• Publication Date: 2021-10
• Subjects: ABS dermal absorption factor -- B&A Bland-Altman -- BBP butyl-benzyl-phthalate -- BM biomonitoring -- BW body weight -- cx-MiNP mono-4-methyl-7-carboxyoctyl phthalate -- DBP di-n-butyl phthalate -- DEHP di (2-ethylhexyl) phthalate -- DEP diethyl phthalate -- DiBP Diisobutyl phthalate -- DINCH di(isononyl)cyclohexane-1, 2-clicarboxylate -- DINP di-iso-nonyl phthalate -- EFSA European Food Safety Authority -- HBGV health-based guidance values -- LB lower bound -- LOD limit of detection -- LOQ limit of quantification -- MB medium bound -- MBzP monobenzyl phthalate -- MECPP mono-2-ethyl 5-carboxypentyl phthalate -- MEHHP mono-2-ethyl-5-hydroxyhexyl phthalate -- MEHP mono-2-ethylhexyl phthalate -- MEOHP mono-2-ethyl-5-oxohexyl phthalate -- MEP monoethyl phthalate -- MiBP mono-iso-butyl phthalate -- MMCHP mono-2-carboxymethyl hexyl phthalate -- oh-MINCH 2-(((hydroxy-4-methyloctyl)oxy)carbonyl)-cyclohexanecarboxylic acid -- oh-MiNP mono-4-methyl-7-hydroxyoctyl phthalate -- oh-MPHP 6-hydroxy monopropylheptylphthalate -- oxo-MINCH 2-(((4-Methyl-7-oxyooctyl)oxy)carbonyl)-cyclohexanecarboxylic acid -- oxo-MiNP mono-4-methyl-7-oxooctyl phthalate -- MnBP mono-n-butyl phthalate -- ND non-detects -- PCPs personal care products -- PVC polyvinyl chloride -- RPF Relative Potency Factor -- TDI tolerable daily intake -- TDS total diet study -- UB upper bound -- WHO World Health Organization; Phthalate -- DINCH -- Biomonitoring -- Food -- Personal care products; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2021.106598
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Phthalates are diesters of phthalic acid and have been widely used as plasticizers in polyvinyl chloride (PVC) plastics. Phthalates are also used as excipients in pharmaceuticals and personal care products (PCPs). Phthalates can migrate from the plastic into the air, water and food, and humans can be exposed via multiple pathways such as dermal, oral and inhalation. There is evidence that phthalates can induce reproductive and developmental toxicity not only in experimental animals but also in humans through disruption of estrogenic activity. The aim of this study was to collect concentration data on five phthalates in foods and PCPs from the scientific literature and combine these with food consumption data and PCP use frequency data from the EuroMix biomonitoring (BM) study in order to assess exposure. Probabilistic exposure assessments of phthalates were performed from foods and PCPs. Due to the very limited data available in the literature for DINCH, an exposure assessment was not carried out for this compound. The food groups with the highest contribution to phthalates exposure were: beverages, dairy, bread and meat products. The exposure estimates were compared with the measured phthalate metabolite levels from 24-hour urine samples. Regarding the oral route, measured phthalate exposure was between the lower bound (LB) and medium bound (MB) estimated exposure for all phthalates, except for DEP. The measured exposure from urine correlated with the estimated exposure from food for DEHP and DBP, while for BBP and DEP it correlated with the exposure estimates from PCPs. There were no significant differences between the BM data and the estimated exposure, except for DINP for males (p = 0.01). The LB and MB phthalate exposures estimated from foods and PCPs and the measured exposure from the urine were considerably lower than their respective tolerable daily intake (TDI) values established by the European Food Safety Authority (EFSA) and the World Health Organization (WHO). For the upper bound (UB), the exposure estimates are approximately double the TDI; however, this is regarded as a worst-case estimate and has low correlation with the measured exposure.