Enhancing Rechargeable Persistent Luminescence via Organic Dye Sensitization. (20th May 2021)

• Record Type: Journal Article
• Authors: Li, Zhanjun; Zhao, Yang; Huang, Kai; Huang, Ling; Zhang, Yuanwei; Yang, Hong; Han, Gang
• Is Part Of: Angewandte Chemie. Volume 133:Number 29(2021)
• Page Start: 16022
• Page End: 16026
• Publication Date: 2021-05-20
• Subjects: dye sensitization -- guided surgery -- imaging -- near infrared -- persistent luminescence; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202101492
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Owing to their unique afterglow ability, long‐wavelength light activatable persistent luminescence (PersL) nanoparticles (PLNPs) have been emerging as an important category of imaging probes. Long‐wavelength LED light has been shown to be effective in recharging these nanoparticles. However, finding a simple and effective method to amplify such renewable PersL signals under long‐wavelength light is still a key challenge. Herein, we discovered that a dye‐sensitization strategy was able to effectively boost the renewable PersL signals of the NIR emitting ZnGa2 O4 :Cr 3+ (ZGC)) under long‐wavelength LED light. Moreover, as a proof‐of‐principle tumorectomy demonstration, this new class of dye sensitized ZGC enabled simultaneous intraoperative anatomic tumor navigation and effective microscopic detection of tumor cells in pathological diagnosis. Abstract : A simple dye‐sensitization strategy was discovered to boost the rechargeable persistent luminescence performance of the persistent luminescence nanoparticles. The dye sensitized nanoparticles are used for PersL imaging guided tumorectomy. They provide simultaneous enhanced signal‐to‐background afterglow intraoperative anatomic tumor navigation and simple microscopic fluorescent cellular imaging.