A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity. (24th April 2013)

• Record Type: Journal Article
• Authors: Sontakke, Vyankat A.; Ghosh, Sougata; Lawande, Pravin P.; Chopade, Balu A.; Shinde, Vaishali S.
• Other Names: Chand D. K. Academic Editor.; Gattuso G. Academic Editor.; Menéndez J. C. Academic Editor.
• Is Part Of: ISRN organic chemistry. Volume 2013(2013)
• Publication Date: 2013-04-24
• Subjects: Chemistry, Organic -- Periodicals; Organic Chemistry Phenomena; Chemistry, Organic; Chemistry, Organic; Periodical; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 547
• DOI: 10.1155/2013/453682
• Languages: English
• ISSNs: 2090-5149

Abstract

Abstract : A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5 IO6 -SiO2 ) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.