Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine. (26th August 2013)

• Record Type: Journal Article
• Authors: Attia, Mohamed I.; Ghabbour, Hazem A.; Almutairi, Maha S.; Ghoneim, Soraya W.; Abdel-Aziz, Hatem A.; Fun, Hoong-Kun
• Other Names: Marandi Farzin Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2013(2013)
• Publication Date: 2013-08-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2013/418601
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Synthesis and characterization of (1E )-1-(4-chlorophenyl)- N -hydroxy-3-(1H -imidazol-1-yl)propan-1-imine (4 ) are reported. X-ray crystal structure of the title oxime 4 confirmed its assigned ( E )-configuration. The compound crystallizes in the monoclinic space group P 21/c with a = 13.4292 (3) Å, b = 8.8343 (2) Å, c = 11.1797 (3) Å, α = 90 °, β = 108.873 (2)°, γ = 90 °, V = 1255.03 (5) Å 3, and Z = 4 . The molecules are packed in crystal structure by weak intermolecular O – H ⋯ N hydrogen bonding interactions. Compound 4 is a useful intermediate for the synthesis of new imidazole-containing antifungal agents.