Au/In2O3 Nanocubes Based Label‐free Aptasensor for Ultrasensitive and Rapid Recognition of Cardiac Troponin I. Issue 7 (26th May 2021)

• Record Type: Journal Article
• Authors: Xu, Weijia; Liu, Tao; Wang, Yiqing; Zhang, Wei; Yao, Xiaoyue; Hou, Bailing; Xie, Ying; Chu, Zhenyu; Jin, Wanqin
• Is Part Of: Electroanalysis. Volume 33:Issue 7(2021)
• Page Start: 1810
• Page End: 1818
• Publication Date: 2021-05-26
• Subjects: Au/In2O3 nanocubes -- label-free aptasensor -- rapid detection -- cardiac troponin I -- high sensitivity; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202100117
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: Cardiac Troponin I (cTnI) is a preferred biomarker to diagnose acute myocardial infarction which is one of the leading risks to health globally due to its short term. However, clinical analyzers are difficult to achieve its on‐site quantitative detection. A novel label‐free aptasensor was constructed to realize ultrasensitive and rapid recognition of cTnI. A nanocubic AuNPs/In2 O3 composite was designed to provide synergistic effects of abundant active sites and signal magnification for aptamers grafting. Relying on a conductance‐dependence strategy, this aptasensor can achieve the quantitative detection within 10 min, which is much faster than state‐of‐the‐art analyzers, as well as exhibiting an ultrawide linear range of 0.1–1000 ng/mL and a low detection limit of 0.06 ng/mL with an excellent selectivity in the analysis of human serum. Abstract :