Effect of Propofol on Acid Reflux Measured with the Bravo pH Monitoring System. (22nd April 2013)

• Record Type: Journal Article
• Authors: Chawla, Anupama; Girda, Eugenia; Walker, Grace; Turcotte Benedict, Frances; Tempel, Mila; Morganstern, Jeffrey
• Other Names: Amedei A. Academic Editor.; Shun C.-T. Academic Editor.; Te Velde A. A. Academic Editor.; Weimann A. Academic Editor.
• Is Part Of: ISRN gastroenterology. Volume 2013(2013)
• Publication Date: 2013-04-22
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases; Gastroenterology; Gastroenterology; Gastrointestinal Diseases; Fulltext; Internet Resources; Periodicals; Electronic journals; Periodicals; Periodical; 616.3
• DOI: 10.1155/2013/605931
• Languages: English
• ISSNs: 2090-4398

Abstract

Abstract : Background/Aim . The aim of this study was to determine the effect of propofol on acid reflux as measured with the Bravo pH monitoring system. Methods . 48-hour pH tracings of 88 children were retrospectively evaluated after placement of the Bravo capsule under propofol. Comparisons between day 1 and day 2, as well as 6-hour corresponding segments from day 1 and day 2, were made. Results . The number of reflux episodes was significantly increased during the first six-hour period on day one as compared to day 2 ( P = 0.006 ) . The fraction of time the pH was <4 was also increased during this period, though it did not reach statistical significance. When comparing full 24-hour periods, there was no difference noted in either the number of reflux episodes or the fraction of time pH < 4 between day one and day two. Conclusion . Our data suggest an increase in gastroesophageal reflux during the postanesthesia period. This could be a direct effect of propofol, or related to other factors. Regardless of the cause, monitoring of pH for the first 6 hours following propofol administration may not be reliable when assessing these patients. Monitoring pH over a prolonged 48-hour time period can overcome this obstacle.