Analysis of the diagnostic capabilities of urinary neutrophil gelatinase‐associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission. Issue 7 (8th June 2021)

• Record Type: Journal Article
• Authors: Imoto, Yuji; Wakasaki, Ayano; Izumida, Kumiko; Shimada, Hiroshi; Ohkubo, Kumiko; Kawano, Yasumasa; Ishikura, Hiroyasu; Matsunaga, Akira
• Is Part Of: Journal of clinical laboratory analysis. Volume 35:Issue 7(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-08
• Subjects: acute kidney Injury -- NGAL -- pancreatitis -- procalcitonin -- sepsis; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.23852
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: Acute kidney injury (AKI) is a disease that negatively affects patient prognosis and requires early diagnosis and treatment. Biomarkers that predict AKI are needed for early diagnosis of this disease. Methods: We compared the AKI group and the non‐AKI group in patients who were admitted to our critical care intensive care unit (ICU) and conducted a comparative study focusing on urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) and serum procalcitonin (PCT). Results: Seventy‐one out of 106 ICU inpatients were diagnosed with AKI in accordance with the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Among the patients who were diagnosed with AKI stages 1 to 3, 94.4% of all patients reached the maximum stage by day 5 after admission. Comparing the non‐AKI group and AKI stage 1 to 3 on days 1 to 3 after admission, U‐NGAL and PCT levels in the stage 3 group were significantly higher than those in the non‐AKI group. Additionally, in receiver operating characteristic curve (ROC) analysis on days 1–3 after admission, U‐NGAL and PCT levels can be used as biomarkers for the diagnosis of AKI, and in particular, AKI stage 3 can be predicted and diagnosed with high accuracy. U‐NGAL and PCT levels were also significantly higher in AKI due to sepsis and acute pancreatitis and due to sepsis, respectively. Conclusions: Measuring U‐NGAL and PCT levels as biomarkers for AKI may further improve the accuracy of AKI diagnosis in critical care ICU. Abstract : In receiver operating characteristic curve (ROC) analysis, urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) and serum procalcitonin (PCT) levels can be used as biomarkers for the diagnosis of acute kidney injury (AKI) after critical care ICU admission. The figures show the ROC analysis and area under the curve (AUC) of U‐NGAL and PCT in AKI stage 3 patients on day 2 after admission.