Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients. (22nd August 2013)

• Record Type: Journal Article
• Authors: Syed Ahamed Kabeer, Basirudeen; Selvaraj, Anbalagan; Raja, Alamelu
• Other Names: Artlett C. M. Academic Editor.; Taylor-Robinson A. Academic Editor.
• Is Part Of: ISRN immunology. Volume 2013(2013)
• Publication Date: 2013-08-22
• Subjects: Immunology -- Periodicals; Immunology; Allergy and Immunology -- Periodicals; Immune System -- Periodicals; Immune System Diseases -- Periodicals; Periodicals; Electronic journals; 616.079
• DOI: 10.1155/2013/794962
• Languages: English
• ISSNs: 2090-5645

Abstract

Abstract : This study assessed the polyfunctional T cells in healthy household contacts (HHCs) and TB patients. This study also assessed the memory subsets responsible for the secretion of IFN- γ during the short-term culture with Mycobacterium tuberculosis antigens. Frequencies of CD4 + IFN- γ + TNF- α + T cells and CD8 + IFN- γ + TNF- α + T cells specific to M. tuberculosis antigens were significantly higher in TB patients compared to HHC. IFN- γ -secreting T cells, during overnight stimulation with M. tuberculosis antigens, belonged to effector memory subset with a CD45RA − CD27 − phenotype. However, the number of IFN- γ -secreting effector memory cells did not differ between HHC and TB patients.