Laryngeal Involvement of Multiple Myeloma. (18th November 2012)

• Record Type: Journal Article
• Authors: Grobman, Ariel B.; Vivero, Richard J.; Campuzano-Zuluaga, German; Ganjei-Azar, Parvin; Rosow, David E.
• Other Names: Buchanich J. M. Academic Editor.; Mayordomo J. I. Academic Editor.; Razzouk B. I. Academic Editor.; Vandoros G. P. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2012(2012)
• Publication Date: 2012-11-18
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2012/257814
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as "metastatic" multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.