Electrochemical Biosensor Design with Multi‐walled Carbon Nanotube to Display DNA‐Schiff Base Interaction. Issue 7 (27th April 2021)

• Record Type: Journal Article
• Authors: Munir, Azeema; Bozal‐Palabiyik, Burcin; Eren, Gokcen; Shah, Afzal; Ali, Saqib; Uddin, Noor; Uslu, Bengi
• Is Part Of: Electroanalysis. Volume 33:Issue 7(2021)
• Page Start: 1761
• Page End: 1770
• Publication Date: 2021-04-27
• Subjects: Schiff base -- DNA biosensor -- carbon nanotube -- voltammetry -- molecular docking; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202100156
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: This paper demonstrates a Schiff base i. e. 5‐(diethylamino)‐2‐((2, 6‐diethylphenylimino)methyl)phenol (5‐DDMP) that was sensed by DNA biosensor. dsDNA was immobilized onto GCE modified with functionalized multi‐walled carbon nanotubes to prepare a biosensor. The efficiency of dsDNA biosensor was determined and binding of 5‐DDMP with dsDNA was searched by UV‐vis spectrophotometry and differential pulse voltammetry. Molecular docking simulations between 5‐DDMP and dsDNA were explored and as a result, a hydrogen bond and a π‐π contact were observed between 5‐DDMP and deoxyguanosine base (dG22) of the strand B, deoxyadenosine base (dA5) of the strand A, respectively. These studies could be useful for new anticancer drug design and development. Abstract :