Adjuvant Use of Ivabradine in Acute Heart Failure due to Myocarditis. (27th September 2011)

• Record Type: Journal Article
• Authors: Franke, Jennifer; Schmahl, Dorothee; Lehrke, Stephanie; Pribe, Regina; Bekeredjian, Raffi; Doesch, Andreas O.; Ehlermann, Philipp; Schnabel, Philipp; Katus, Hugo A.; Zugck, Christian
• Other Names: Firstenberg Michael S. Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2011(2011)
• Publication Date: 2011-09-27
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2011/203690
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : We report two cases of young men in whom acute heart failure due to myocarditis was diagnosed. The patients had been transferred to the intensive care unit (ICU) with commencing symptoms of acute heart failure and consecutive multiorgan failure for further treatment and to evaluate the indication for implantation of a ventricular assist device or for high urgent orthotopic heart transplantation. In both patients, the I f -channel inhibitor ivabradine was administered off-label to provide selective heart rate reduction, and thus support hemodynamic stabilization. Though currently considered off-label use in patients suffering from severe hypotension and acute heart failure, the use of ivabradine may beneficially influence outcome by allowing optimization of the patient's heart rate concomitant to initial measures of clinical stabilization.